SML2532
Jedi2
≥98% (HPLC)
Synonym(s):
2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C10H8O3S
CAS Number:
Molecular Weight:
208.23
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Product Name
Jedi2, ≥98% (HPLC)
SMILES string
[s]1c(ccc1)c2[o]c(c(c2)C(=O)O)C
InChI
1S/C10H8O3S/c1-6-7(10(11)12)5-8(13-6)9-3-2-4-14-9/h2-5H,1H3,(H,11,12)
InChI key
YXDCRSXNEOKXDE-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Jedi2 is an activator of the mechanosensitive Piezo1 channel that binds at a different place from Yoda1. It exhibits long-range allosteric gating, activating Piezo1 through the extracellular side of its peripheral blade-like structure rather than the C-terminal extracellular domain of the pore.
Piezo1 channel activator
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Taylor D Skokan et al.
Molecular biology of the cell, 35(3), br9-br9 (2024-01-24)
Cells rely on a diverse array of engulfment processes to sense, exploit, and adapt to their environments. Among these, macropinocytosis enables indiscriminate and rapid uptake of large volumes of fluid and membrane, rendering it a highly versatile engulfment strategy. Much
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