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Safety Information

SML2364

Sigma-Aldrich

4-Androstenedione

≥98% (HPLC)

Synonym(s):

4-Androstene-3,17-dione, (8R,9S,10R,13S,14S)-10,13-dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3H-cyclopenta[a]phenanthrene-3,17(2H)-dione, 17-Ketotestosterone, 3,17-Dioxoandrost-4-ene, Androst-4-ene-3,17-dione, Androstenedione, Fecundin, NSC 9563, SKF 2170

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About This Item

Empirical Formula (Hill Notation):
C19H26O2
CAS Number:
63-05-8
Molecular Weight:
286.41
Beilstein:
2059239
MDL number:
MFCD00003615
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule III

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)C(=O)CC[C@@]24[H]

InChI

1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1

InChI key

AEMFNILZOJDQLW-QAGGRKNESA-N

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Biochem/physiol Actions

4-Androstenedione, commonly known as Androstenedione, is an endogenous androgen steroid hormone. 4-Androstenedione functions as an intermediate in the biosynthesis of testosterone, estradiol and estrone. Recent studies indicate that 4-Androstenedione is involved in aromatase inhibitors induce painful musculoskeletal symptoms (AIMSS) by activation of TRPA1.
Testosterone precursor and metabolite with androgenic activity; may increase the risk of prostate or pancreatic cancer.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H351,H360FD,H362

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Lact. - Repr. 1A

WGK

WGK 2

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Francesco De Logu et al.
Cancer research, 76(23), 7024-7035 (2016-10-21)
Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of patients, we hypothesized

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