SML2300
ADA-07
≥95% (HPLC)
Synonym(s):
5-(adamantan-1-yl)-3-(hydroxyimino) indolin-2-one
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About This Item
Empirical Formula (Hill Notation):
C18H20N2O2
CAS Number:
Molecular Weight:
296.36
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Assay
≥95% (HPLC)
form
powder
color
yellow to brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(/C1=N\O)NC(C1=C2)=CC=C2C34C[C@@H](C5)C[C@@H](C[C@@H]5C4)C3
Biochem/physiol Actions
ADA-07 is a potent and selective T-LAK cell-originated protein kinase (TOPK) inhibitor that binds to ATP-binding pocket. ADA-07 suppresses SUV-induced phosphorylation of ERK1/2, p38, and JNKs and subsequently inhibited AP-1 activity, and reduces SUV-induced skin carcinogenesis.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Ge Gao et al.
Molecular cancer therapeutics, 16(9), 1843-1854 (2017-06-29)
Cumulative exposure to solar ultraviolet (SUV) irradiation is regarded as the major etiologic factor in the development of skin cancer. The activation of the MAPK cascades occurs rapidly and is vital in the regulation of SUV-induced cellular responses. The T-LAK
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