All Photos(1)
Synonym(s):
(R)-ethyl 1-(1-(3,5-dimethoxyphenyl)ethyl)-1H-imidazole-5-carboxylate
Empirical Formula (Hill Notation):
C16H20N2O4
Recommended Products
Assay
≥98% (HPLC)
form
oil
color
colorless to light brown
storage temp.
2-8°C
SMILES string
C[C@@H](N1C=NC=C1C(OCC)=O)C2=CC(OC)=CC(OC)=C2
Biochem/physiol Actions
Dimethyoxy-etomidate is a phenyl ring substituted etomidate analog.
Dimethyoxy-etomidate is a potent suppressor of adrenocortical steroid synthesis by inhibiting steroid 11β-hydroxylase. Dimethyoxy-etomidate is essentially divided of etomidate′s GABAA receptor positive modulatory and sedative-hypnotic activities.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Megan McGrath et al.
The Journal of pharmacology and experimental therapeutics, 364(2), 229-237 (2017-12-06)
Cushing's syndrome is characterized by the overproduction of adrenocortical steroids. Steroidogenesis inhibitors are mainstays of medical therapy for Cushing's syndrome; unfortunately, adverse side effects and treatment failures are common with currently available drugs. The general anesthetic induction agent etomidate is
Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
McGrath M, et al.
BMC Pharmacology & Toxicology, 20, 1-9 (2019)
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