SML2295
Dimethyoxy-etomidate
≥98% (HPLC)
Synonym(s):
(R)-ethyl 1-(1-(3,5-dimethoxyphenyl)ethyl)-1H-imidazole-5-carboxylate
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About This Item
Empirical Formula (Hill Notation):
C16H20N2O4
CAS Number:
Molecular Weight:
304.34
UNSPSC Code:
12352200
NACRES:
NA.21
InChI
1S/C16H20N2O4/c1-5-22-16(19)15-9-17-10-18(15)11(2)12-6-13(20-3)8-14(7-12)21-4/h6-11H,5H2,1-4H3/t11-/m1/s1
InChI key
JETTTZITBCWAQX-LLVKDONJSA-N
SMILES string
C[C@@H](N1C=NC=C1C(OCC)=O)C2=CC(OC)=CC(OC)=C2
assay
≥98% (HPLC)
form
oil
color
colorless to light brown
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
Dimethyoxy-etomidate is a phenyl ring substituted etomidate analog.
Dimethyoxy-etomidate is a potent suppressor of adrenocortical steroid synthesis by inhibiting steroid 11β-hydroxylase. Dimethyoxy-etomidate is essentially divided of etomidate′s GABAA receptor positive modulatory and sedative-hypnotic activities.
potent suppressor of adrenocortical steroid synthesis, selective inhibitor of steroid 11β-hydroxylase
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Behavioral and steroidogenic pharmacology of phenyl ring substituted etomidate analogs in rats
McGrath M, et al.
BMC Pharmacology & Toxicology, 20, 1-9 (2019)
Megan McGrath et al.
The Journal of pharmacology and experimental therapeutics, 364(2), 229-237 (2017-12-06)
Cushing's syndrome is characterized by the overproduction of adrenocortical steroids. Steroidogenesis inhibitors are mainstays of medical therapy for Cushing's syndrome; unfortunately, adverse side effects and treatment failures are common with currently available drugs. The general anesthetic induction agent etomidate is
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