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SML2141

Sigma-Aldrich

Solifenacin succinate

≥98% (HPLC)

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Synonym(s):
(1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4­dihydro-1-phenyl-2(1H)-iso-quinolinecarboxylate succinate, YM905
Empirical Formula (Hill Notation):
C23H26N2O2 · C4H6O4
CAS Number:
242478-38-2
Molecular Weight:
480.55
MDL number:
MFCD00954234
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +35 to +45°, c = 1 in H2O

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC(CCC(O)=O)=O.O=C(O[C@H]1CN2CCC1CC2)N3[C@@H](C4=CC=CC=C4)C5=CC=CC=C5CC3

InChI

1S/C23H26N2O2.C4H6O4/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;5-3(6)1-2-4(7)8/h1-9,18,21-22H,10-16H2;1-2H2,(H,5,6)(H,7,8)/t21?,22-;/m0./s1

InChI key

RXZMMZZRUPYENV-DZSUWJOWSA-N

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Biochem/physiol Actions

Solifenacin succinate (SOL) blocks the cholinergic signals to M3 receptors by inhibiting the muscarinic M3 receptors in the bladder. This action prevents the contractions of the detrusor muscles in the urinary bladder wall, leading to relaxing the bladder as well as decreasing urinary urgency and nocturia. Thus, SOL is a widely used antimuscarinic agent for treating the contraction of the overactive bladder.

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H361d

Hazard Classifications

Repr. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Yoshihiko Ito et al.
Biological & pharmaceutical bulletin, 39(7), 1167-1171 (2016-07-05)
Solifenacin is an antimuscarinic agent used to treat symptoms of overactive bladder. Pharmacologically significant amounts of solifenacin were excreted in the urine of humans taking a clinical dose of this drug. The aim of this study is to measure muscarinic
Stability-indicating HPTLC method for the simultaneous detection and quantification of alfuzosin hydrochloride, solifenacin succinate along with four of their official impurities
Tantawy MA, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 157, 104905-104905 (2020)
Donald Newgreen et al.
The Journal of urology, 198(4), 928-936 (2017-05-17)
We evaluated the long-term safety and efficacy of once daily oral solifenacin suspension in children (5 to less than 12 years old) and adolescents (12 to less than 18 years old) with overactive bladder. We conducted a 40-week, open label extension
Molecular docking of different ionophores host-guest inclusion complexes for electrochemical determination of solifenacin succinate in pure and pharmaceutical dosage form: Computer aided design
Eissa MS, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 159, 105363-105363 (2020)
Tomomi Oki et al.
British journal of pharmacology, 145(2), 219-227 (2005-03-09)
1 A novel muscarinic receptor antagonist, solifenacin succinate, inhibited specific binding of [N-methyl-(3)H]-scopolamine ([(3)H]-NMS) in the mouse bladder, submaxillary gland and heart in a concentration-dependent manner. This inhibitory effect was greatest in the submaxillary gland, followed by the bladder and

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