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Merck
CN

SML2127

Dynapyrazole-A

≥98% (HPLC)

Synonym(s):

2-[1-(4-Chloro-phenyl)-cyclopropyl]-7-iodo-5-oxo-4,5-dihydro-pyrazolo[1,5-a]quinazoline-3-carbonitrile

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About This Item

Empirical Formula (Hill Notation):
C20H12ClIN4O
CAS Number:
2226517-75-3
Molecular Weight:
486.69
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

IC1=CC=C(N2C(NC3=O)=C(C#N)C(C4(CC4)C5=CC=C(Cl)C=C5)=N2)C3=C1

InChI

1S/C20H12ClIN4O/c21-12-3-1-11(2-4-12)20(7-8-20)17-15(10-23)18-24-19(27)14-9-13(22)5-6-16(14)26(18)25-17/h1-6,9H,7-8H2,(H,24,27)

InChI key

VABPBCMFKJDOHP-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Dynapyrazole-A is a potent dynein inhibitor. Dynapyrazole-A inhibits microtubule activity without inhibiting basal ATPase activity.
Dynein inhibitor

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000366051
0000366052
0000358313
0000366051
0000366052

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Jonathan B Steinman et al.
eLife, 6 (2017-05-20)
Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that transport cellular cargos toward microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-class inhibitors, the use of ciliobrevins has in
Alexander S Zhovmer et al.
Science advances, 10(1), eadi1788-eadi1788 (2024-01-04)
The all-terrain motility of lymphocytes in tissues and tissue-like gels is best described as amoeboid motility. For amoeboid motility, lymphocytes do not require specific biochemical or structural modifications to the surrounding extracellular matrix. Instead, they rely on changing shape and
Alexander S Zhovmer et al.
ACS nano, 15(11), 17528-17548 (2021-10-23)
Microtubules (MTs) and MT motor proteins form active 3D networks made of unstretchable cables with rod-like bending mechanics that provide cells with a dynamically changing structural scaffold. In this study, we report an antagonistic mechanical balance within the dynein-kinesin microtubular

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