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SML2094

Sigma-Aldrich

BIBO 3304 trifluoroacetate salt

≥98% (HPLC)

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Synonym(s):
BIBO3304, N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-a-phenyl-benzeneacetamide trifluoroacetate
Empirical Formula (Hill Notation):
C29H35N7O3 · xC2HF3O2
CAS Number:
191868-13-0
Molecular Weight:
529.63 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C29H35N7O3/c30-28(31)33-17-7-12-24(26(37)34-18-20-13-15-21(16-14-20)19-35-29(32)39)36-27(38)25(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-6,8-11,13-16,24-25H,7,12,17-19H2,(H,34,37)(H,36,38)(H4,30,31,33)(H3,32,35,39)/t24-/m1/s1

InChI key

TVMJSGGZULFVCZ-XMMPIXPASA-N

Related Categories

Biochem/physiol Actions

BIBO 3304 is a highly potent and selective NPY Y1 receptor antagonist that inhibits food intake induces by NPY (neuropeptide Y) or fasting in rodents. BIBO3304 eliminates NPY effects on fear extinction retrieval in rats.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Lauren L Vollmer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(4), 1306-1315 (2016-01-29)
Neuropeptide Y (NPY), a 36 aa peptide, regulates stress and emotional behaviors. Preclinical and clinical studies support an association of NPY with trauma-evoked syndromes such as posttraumatic stress disorder (PTSD), although the exact contribution of NPY is not clear. In
H A Wieland et al.
British journal of pharmacology, 125(3), 549-555 (1998-11-07)
1. The novel Y1-selective argininamide derivative BIBO 3304 ((R)-N-[[4-(aminocarbonylaminomethyl)-phenyl]methyl]-N2-(diphen ylacetyl)-argininamide trifluoroacetate) has been synthesized and was examined for its subtype selectivity, its in vitro antagonistic properties and its food intake inhibitory properties. 2. BIBO 3304 displayed subnanomolar affinity for both
Shlomi Cohen et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(3), 774-790 (2014-09-23)
The hypothalamic-pituitary-adrenal (HPA) axis displays a characteristic circadian pattern of corticosterone release, with higher levels at the onset of the active phase and lower levels at the onset of the inactive phase. As corticosterone levels modify the response to stress

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