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Safety Information

SML2072

Sigma-Aldrich

OX03050

≥98% (HPLC)

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Synonym(s):
(E)-3-(4-Styrylphenoxy)propan-1-ol, 3-[4-[(1E)-2-Phenylethenyl]phenoxy]-1-propanol
Empirical Formula (Hill Notation):
C17H18O2
CAS Number:
Molecular Weight:
254.32
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

OX03050 is a metabolically stable, potent and selective squalene synthase inhibitor that upregulates the Low-Density Lipoprotein Receptor (LDLR) in mouse and in human liver cell lines. OX03050 used in conjunction with statin acts synergistically to increase LDLR expression

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Alastair G Kerr et al.
The Journal of pharmacology and experimental therapeutics, 361(3), 417-428 (2017-04-01)
Hypercholesterolemia remains one of the leading risk factors for the development of cardiovascular disease. Many large double-blind studies have demonstrated that lowering low-density lipoprotein (LDL) cholesterol using a statin can reduce the risk of having a cardiovascular event by approximately

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