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SEA0400, 2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine, SEA 0400
C21H19F2NO3
Recommended Products
Assay
≥98% (HPLC)
form
powder
color
white to beige
shipped in
ambient
storage temp.
−20°C
SMILES string
CCOC1=CC=C(OC2=CC=C(OCC3=C(F)C=CC(F)=C3)C=C2)C(N)=C1
InChI
1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3
InChI key
YSUBLPUJDOWYDP-UHFFFAOYSA-N
Biochem/physiol Actions
SEA0400 is a potent and selective inhibitor of Na+/Ca2+exchanger (NCX). SEA0400 potently inhibits Na+/Ca2+ exchanger activity in rat astrocytes, microglia, cultured neurons, and rat cardiomyocytes.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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European journal of pharmacology, 788, 286-293 (2016-07-05)
The Na(+)/Ca(2+) exchanger (NCX) plays a major role in myocardial Ca(2+) homoeostasis, but is also considered to contribute to the electrical instability and contractile dysfunction in chronic atrial fibrillation (AF). Here we have investigated the effects of the selective NCX
The Journal of pharmacology and experimental therapeutics, 298(1), 249-256 (2001-06-16)
The effect of the newly synthesized compound 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400) on the Na+-Ca2+ exchanger (NCX) was investigated and compared against that of 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea (KB-R7943). In addition, the effects of SEA0400 on reperfusion injury in vitro and in vivo were examined. SEA0400
Naunyn-Schmiedeberg's archives of pharmacology, 389(11), 1205-1214 (2016-08-03)
Recently, YM-244769 (N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide) has been reported as a new potent and selective Na+/Ca2+ exchange (NCX) inhibitor by using various cells transfected with NCX using the 45Ca2+ fluorescent technique. However, the electrophysiological study of YM-244769 on NCX had not been
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