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Merck
CN

SML2004

Cangrelor tetrasodium salt

≥95% (HPLC), P2Y12 antagonist, powder

Synonym(s):

AR-C69931 tetrasodium salt, AR-C69931MX tetrasodium salt, N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, anhydride with P,P′-(dichloromethylene)bis[phosphonic acid]-5′-Adenylic acid tetrasodium salt

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About This Item

Empirical Formula (Hill Notation):
C17H21Cl2F3N5O12P3S2·Na4
CAS Number:
163706-36-3
Molecular Weight:
864.29
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Cangrelor tetrasodium salt, ≥95% (HPLC)

SMILES string

O[C@@H]1[C@H](O)[C@@H](COP(OP(C(Cl)(Cl)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)O[C@H]1N(C=N2)C3=C2C(NCCSC)=NC(SCCC(F)(F)F)=N3

InChI

1S/C17H25Cl2F3N5O12P3S2.4Na/c1-43-5-3-23-12-9-13(26-15(25-12)44-4-2-16(20,21)22)27(7-24-9)14-11(29)10(28)8(38-14)6-37-42(35,36)39-41(33,34)17(18,19)40(30,31)32;;;;/h7-8,10-11,14,28-29H,2-6H2,1H3,(H,33,34)(H,35,36)(H,23,25,26)(H2,30,31,32);;;;/q;4*+1/p-4/t8-,10-,11-,14-;;;;/m1..../s1

InChI key

COWWROCHWNGJHQ-OPKBHZIBSA-J

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

Related Categories

Application

Cangrelor has been used as a purinergic receptor P2Y12 antagonist to study its effects on neuromedin U receptor 2 (NMUR2)-coupled Gαi pathway during platelet aggregation.

Biochem/physiol Actions

Cangrelor is a potent and selective platelet P2Y12 antagonist. It is used as an intravenous antiplatelet drug to prevent formation of harmful blood clots in the coronary arteries.
Cangrelor is an analog of nonthienopyridine adenosine triphosphate. It has a therapeutic effect against reversible platelet inhibition.
Potent and selective platelet P2Y12 antagonist

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000457674
0000457673
0000457674
0000457673
0000383173

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Platelet inhibition with cangrelor in patients undergoing PCI
Harrington R A, et al.
The New England Journal of Medicine, 361(24), 2318-2329 (2009)
Neuromedin U potentiates ADP-and epinephrine-induced human platelet activation
Grippi C, et al.
Thrombosis Research, 159(24), 100-108 (2017)
Erika Cecon et al.
Cell chemical biology (2021-07-12)
Targeting the interaction between the SARS-CoV-2 spike protein and human ACE2, its primary cell membrane receptor, is a promising therapeutic strategy to prevent viral entry. Recent in vitro studies revealed that the receptor binding domain (RBD) of the spike protein plays

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