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SML2004

Sigma-Aldrich

Cangrelor tetrasodium salt

≥95% (HPLC)

Synonym(s):

AR-C69931 tetrasodium salt, AR-C69931MX tetrasodium salt, N-[2-(methylthio)ethyl]-2-[(3,3,3-trifluoropropyl)thio]-, anhydride with P,P′-(dichloromethylene)bis[phosphonic acid]-5′-Adenylic acid tetrasodium salt

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About This Item

Empirical Formula (Hill Notation):
C17H21Cl2F3N5O12P3S2·Na4
CAS Number:
163706-36-3
Molecular Weight:
864.29
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O[C@@H]1[C@H](O)[C@@H](COP(OP(C(Cl)(Cl)P(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O)O[C@H]1N(C=N2)C3=C2C(NCCSC)=NC(SCCC(F)(F)F)=N3

InChI

1S/C17H25Cl2F3N5O12P3S2.4Na/c1-43-5-3-23-12-9-13(26-15(25-12)44-4-2-16(20,21)22)27(7-24-9)14-11(29)10(28)8(38-14)6-37-42(35,36)39-41(33,34)17(18,19)40(30,31)32;;;;/h7-8,10-11,14,28-29H,2-6H2,1H3,(H,33,34)(H,35,36)(H,23,25,26)(H2,30,31,32);;;;/q;4*+1/p-4/t8-,10-,11-,14-;;;;/m1..../s1

InChI key

COWWROCHWNGJHQ-OPKBHZIBSA-J

Application

Cangrelor has been used as a purinergic receptor P2Y12 antagonist to study its effects on neuromedin U receptor 2 (NMUR2)-coupled Gαi pathway during platelet aggregation.

Biochem/physiol Actions

Cangrelor is a potent and selective platelet P2Y12 antagonist. It is used as an intravenous antiplatelet drug to prevent formation of harmful blood clots in the coronary arteries.
Cangrelor is an analog of nonthienopyridine adenosine triphosphate. It has a therapeutic effect against reversible platelet inhibition.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Platelet inhibition with cangrelor in patients undergoing PCI
Harrington R A, et al.
The New England Journal of Medicine, 361(24), 2318-2329 (2009)
Neuromedin U potentiates ADP-and epinephrine-induced human platelet activation
Grippi C, et al.
Thrombosis Research, 159(24), 100-108 (2017)
Erika Cecon et al.
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