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SML1937

Sigma-Aldrich

SN-6

≥98% (HPLC)

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Synonym(s):
2-[4-(4-Nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester, 4-Thiazolidinecarboxylic acid, 2-[[4-[(4-nitrophenyl)methoxy]phenyl]methyl]-, ethyl ester
Empirical Formula (Hill Notation):
C20H22N2O5S
CAS Number:
415697-08-4
Molecular Weight:
402.46
MDL number:
MFCD06798326
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(OCC)C1CSC(CC2=CC=C(OCC3=CC=C([N+]([O-])=O)C=C3)C=C2)N1

InChI

1S/C20H22N2O5S/c1-2-26-20(23)18-13-28-19(21-18)11-14-5-9-17(10-6-14)27-12-15-3-7-16(8-4-15)22(24)25/h3-10,18-19,21H,2,11-13H2,1H3

InChI key

ZVYIJXLMBWCGHP-UHFFFAOYSA-N

Application

SN-6 has been used as a selective Na+/Ca++ exchanger (NCX) inhibitor to study its neuroprotective effects on axonal injury in mice.

Biochem/physiol Actions

SN-6 is a selective inhibitor of Na+/Ca++ exchanger (NCX) with some selectivity for the NCX1 isoform.
SN-6 is involved in safeguarding against hypoxia and reoxygenation‐induced cell damage in renal tubular cells.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Satomi Kita et al.
Annals of the New York Academy of Sciences, 1099, 529-533 (2007-04-21)
We investigated the pharmacological properties of SN-6, a new selective Na+/Ca2+ exchanger (NCX) inhibitor. SN-6 preferentially inhibited the (45)Ca2+ uptake via NCX compared with the (45)Ca2+ efflux via NCX in NCX-transfected fibroblasts. SN-6 was three- to fivefold more inhibitory to
Anton Omelchenko et al.
Cell death & disease, 10(10), 727-727 (2019-09-29)
Mild traumatic brain injury (mTBI) is a frequently overlooked public health concern that is difficult to diagnose and treat. Diffuse axonal injury (DAI) is a common mTBI neuropathology in which axonal shearing and stretching induces breakdown of the cytoskeleton, impaired

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