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Merck
CN

SML1887

APX2009

≥98% (HPLC)

Synonym(s):

(2E)-2-[(3-methoxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)methylidene]-N,N-diethylpentanamide, 2-[(1,4-Dihydro-3-methoxy-1,4-dioxo-2-naphthalenyl)methylene]-N,N-diethyl-pentanamide

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About This Item

Empirical Formula (Hill Notation):
C21H25NO4
CAS Number:
1415030-15-7
Molecular Weight:
355.43
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

APX2009, ≥98% (HPLC)

InChI

1S/C21H25NO4/c1-5-10-14(21(25)22(6-2)7-3)13-17-18(23)15-11-8-9-12-16(15)19(24)20(17)26-4/h8-9,11-13H,5-7,10H2,1-4H3/b14-13+

InChI key

WEMXCNYTFZUFSB-BUHFOSPRSA-N

SMILES string

O=C1C(OC)=C(/C=C(CCC)/C(N(CC)CC)=O)C(C2=C1C=CC=C2)=O

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

APX2009 is a cell penetrant potent and selective second-generation inhibitor of APE1 redox-signaling that stimulates APE1 DNA repair activity. APX2009 is neuroprotective against cisplatin and oxaliplatin induced toxicity. APX2009 exhibits potent antitumor activity in neuroblastoma cell lines and 3D spheroid pancreatic tumor model.
Cell penetrant potent and selective second-generation inhibitor of APE1 redox-signaling that stimulates APE1 DNA repair activity

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000442424
0000442424
0000438619
0000438619
0000226368

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Mark R Kelley et al.
The Journal of pharmacology and experimental therapeutics, 359(2), 300-309 (2016-10-21)
Chemotherapy-induced peripheral neuropathy (CIPN) is a potentially debilitating side effect of a number of chemotherapeutic agents. There are currently no U.S. Food and Drug Administration-approved interventions or prevention strategies for CIPN. Although the cellular mechanisms mediating CIPN remain to be

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