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Merck
CN

SML1878

GNF-1331

≥98% (HPLC)

Synonym(s):

N-(6-Methoxy-2-benzothiazolyl)-2-[[4-propyl-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-acetamide

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About This Item

Empirical Formula (Hill Notation):
C20H20N6O2S2
CAS Number:
603101-22-0
Molecular Weight:
440.54
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD03750964

Key Documents

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Product Name

GNF-1331, ≥98% (HPLC)

InChI

1S/C20H20N6O2S2/c1-3-10-26-18(13-6-8-21-9-7-13)24-25-20(26)29-12-17(27)23-19-22-15-5-4-14(28-2)11-16(15)30-19/h4-9,11H,3,10,12H2,1-2H3,(H,22,23,27)

SMILES string

CCCN1C(SCC(NC2=NC3=C(C=C(OC)C=C3)S2)=O)=NN=C1C4=CC=NC=C4

InChI key

JIUFLMSAFMXEEC-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

GNF-1331 is an orally available, potent and selective Porcupine (PORCN) inhibitor.
GNF-1331 is an orally available, potent and selective Porcupine inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
027M4602V

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Dai Cheng et al.
ACS medicinal chemistry letters, 7(7), 676-680 (2016-07-21)
Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. We developed and performed a cellular high-throughput screen for inhibitors of Wnt secretion and pathway activation. A lead structure (GNF-1331) was identified from the screen. Further studies

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