SML1835
DSHN
≥98% (HPLC)
Synonym(s):
5-(Diethylsulfamoyl)-3-hydroxynaphthalene-2-carboxylic acid, 5-[(Diethylamino)sulfonyl]-3-hydroxy-2-naphthalenecarboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C15H17NO5S
CAS Number:
Molecular Weight:
323.36
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
CCN(CC)S(C1=CC=CC2=CC(C(O)=O)=C(O)C=C21)(=O)=O
assay
≥98% (HPLC)
form
powder
color
white to brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
DSHN is a potent and selective activator of SHP (small heterodimer partner, NR0B2) that transcriptionally activates SHP mRNA and stabilized the SHP protein by preventing its ubiquitination and degradation. DSHN potently inhibits HCC cell migration and invasivnes by suppression of CCL2 expression.
DSHN is a potent and selective activator of SHP (small heterodimer partner, NR0B2).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Zhihong Yang et al.
Molecular cancer therapeutics, 15(10), 2294-2301 (2016-08-04)
Small heterodimer partner (SHP, NR0B2) is a nuclear orphan receptor without endogenous ligands. Due to its crucial inhibitory role in liver cancer, it is of importance to identify small molecule agonists of SHP. As such, we initiated a probe discovery
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