All Photos(1)
2-(Acetyloxy)-benzoic acid 3-[(nitrooxy)methyl]phenyl ester, 2-Acetoxybenzoic acid 3-nitrooxymethylphenyl ester, 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate, NCX-4016, Nitroaspirin
C16H13NO7
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
−20°C
SMILES string
CC(OC1=CC=CC=C1C(OC2=CC(CO[N+]([O-])=O)=CC=C2)=O)=O
InChI
1S/C16H13NO7/c1-11(18)23-15-8-3-2-7-14(15)16(19)24-13-6-4-5-12(9-13)10-22-17(20)21/h2-9H,10H2,1H3
InChI key
IOJUJUOXKXMJNF-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
NCX 4016 (nitroaspirin) is nitroderivative of aspirin that combines cyclooxygenase inhibitor with an NO donor. NCX 4016 improves postischemic ventricular dysfunction and to reduce myocardial infarct size in rabbit.
NCX-4016 can prevent the progression of cisplatin-resistant human ovarian cancer xenografts in mice. It can also regulate the expression of B-cell lymphoma 2 (Bcl-2) proteins in ovarian cancer cells. Hence, NCX-4016 is considered a promising therapeutic option against carcinoma.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Cell cycle (Georgetown, Tex.), 7(1), 81-88 (2008-01-17)
We have previously reported the inhibitory effect of NCX-4016, a nitro derivative of aspirin, on the proliferation of cisplatin-resistant human ovarian cancer cells, in vitro (Bratasz et al., Proc Natl Acad Sci USA 2006; 103:3914-9). In this report we present
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service