Skip to Content
Merck
CN
All Photos(1)

Documents

SML1614

Sigma-Aldrich

Rp-8-Br-cGMPS sodium salt

≥98% (HPLC)

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
Rp-8-Bromo-cGMPS sodium salt, Rp-8-Bromoguanosine- 3′, 5′- cyclic monophosphorothioate sodium salt
Empirical Formula (Hill Notation):
C10H10BrN5O6PS · Na
CAS Number:
208445-06-1
Molecular Weight:
462.15
MDL number:
MFCD04037242
UNSPSC Code:
12352200
PubChem Substance ID:
329825500
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

lyophilized solid

color

white to beige

storage temp.

−20°C

SMILES string

O=C1C2=C(N([C@@H]3O[C@H](CO[P@@](O4)([O-])=S)[C@@H]4[C@H]3O)C(Br)=N2)N=C(N)N1.[Na+]

InChI

1S/C10H11BrN5O6PS.Na/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(21-8)1-20-23(19,24)22-5;/h2,4-5,8,17H,1H2,(H,19,24)(H3,12,14,15,18);/q;+1/p-1/t2-,4-,5-,8-,23-;/m1./s1

InChI key

CHTSSROWUAICIL-GMKUFTCMSA-M

Related Categories

Biochem/physiol Actions

Rp-8-bromo-cGMPS is a cell permeable cGMP analog that blocks cGMP-dependent protein kinase (cGK, G-kinase, Protein Kinase G, PKG). Rp-8-bromo-cGMPS is resistant to hydrolysis by phosphodiesterases and binds cGK without activating it, resulting in competitive inhibition.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Fan Xu et al.
Frontiers in pharmacology, 11, 523-523 (2020-05-12)
Ischemic stroke remains the leading cause of death and adult disability. Cerebral ischemic/reperfusion (I/R) injury is caused by ischemic stroke thereafter aggravates overwhelming neuronal apoptosis and even the death of neurons. Of note, hippocampus is more susceptive to cerebral I/R

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service