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Safety Information

SML1607

Sigma-Aldrich

Lesinurad

≥98% (HPLC)

Synonym(s):

2-[[5-Bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic acid, RDEA 594

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About This Item

Empirical Formula (Hill Notation):
C17H14BrN3O2S
CAS Number:
878672-00-5
Molecular Weight:
404.28
MDL number:
MFCD22572730
UNSPSC Code:
12352200
PubChem Substance ID:
329825493
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

−20°C

SMILES string

BrC1=NN=C(SCC(O)=O)N1C2=C3C(C=CC=C3)=C(C4CC4)C=C2

InChI

1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)

InChI key

FGQFOYHRJSUHMR-UHFFFAOYSA-N

Gene Information

human ... SLC22A12(116085)

Biochem/physiol Actions

Lesinurad is a selective inhibitor of Urate transporter 1 (URAT1), a urate-anion exchanger which is responsible for the majority of uric acid reabsorption from the renal tubular lumen. Lesinurad thus reduces serum uric acid levels. Lesinurad has been approved for use in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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