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Merck
CN

SML1578

Aftin-4

≥98% (HPLC)

Synonym(s):

(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, Amyloid-β Forty-Two Inducer 4, N6-Methyl-(R)-roscovitine

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About This Item

Empirical Formula (Hill Notation):
C20H28N6O
CAS Number:
866893-90-5
Molecular Weight:
368.48
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

[n]1(c2nc(nc(c2nc1)N(Cc3ccccc3)C)N[C@@H](CO)CC)C(C)C

InChI key

YPYWONAECUVKHY-MRXNPFEDSA-N

InChI

1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000012837
056M4735V

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