All Photos(1)
Synonym(s):
AY-27773, CID 53359, N-[[5 -(Trifluoromethyl)-6-methoxy-lnaphthalenyl]thioxomethyl]-N-methylglycine, N-[[6-Methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methyl-glycine, Tolrestatin
Empirical Formula (Hill Notation):
C16H14F3NO3S
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
InChI
1S/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)
InChI key
LUBHDINQXIHVLS-UHFFFAOYSA-N
Biochem/physiol Actions
Tolrestat is an orally active and potent aldose reductase inhibitor. Studies have also shown that it reduces RBC (red blood cells) sorbitol levels in rats.
Tolrestat is considered to be effective in treating the consequences of diabetes including neuropathy, nephropathy, retinopathy and esophageal motility and vibration perception. Tolrestat is also believed to have lesser or no toxic effects.
WGK
WGK 3
Regulatory Information
新产品
Certificates of Analysis (COA)
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Effect of Tolrestat on oesophageal transit time and cholecystic motility in type 2 diabetic patients with asymptomatic diabetic neuropathy.
Fabiani F, et al.
Diabete & Metabolisme, 21(5), 360-364 (1995)
Principles of diabetes mellitus (2010)
Felicia D'Andrea et al.
Journal of enzyme inhibition and medicinal chemistry, 35(1), 1194-1205 (2020-05-13)
Aldose reductase is a key enzyme in the development of long term diabetic complications and its inhibition represents a viable therapeutic solution for people affected by these pathologies. Therefore, the search for effective aldose reductase inhibitors is a timely and
Susanna Nencetti et al.
Bioorganic & medicinal chemistry, 25(12), 3068-3076 (2017-04-11)
Aldose reductase (ALR2), a NADPH-dependent reductase, is the first and rate-limiting enzyme of the polyol pathway of glucose metabolism and is implicated in the pathogenesis of secondary diabetic complications. In the last decades, this enzyme has been targeted for inhibition
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