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Safety Information

SML1561

Sigma-Aldrich

LP-211

≥98% (HPLC)

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Synonym(s):
6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid 4-cyano-benzylamide, N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide, N-[(4-Cyanophenyl)methyl]-4-[1,1′-biphenyl]-2-yl-1-piperazinehexanamide
Empirical Formula (Hill Notation):
C30H34N4O
CAS Number:
1052147-86-0
Molecular Weight:
466.62
MDL number:
MFCD22690843
UNSPSC Code:
12352200
PubChem Substance ID:
329825965
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

film

color

colorless

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C(NCC1=CC=C(C#N)C=C1)CCCCCN2CCN(C3=CC=CC=C3C4=CC=CC=C4)CC2

InChI

1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35)

InChI key

BQEDZLDNNBDKDS-UHFFFAOYSA-N

Biochem/physiol Actions

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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