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SML1548

Sigma-Aldrich

THPN

≥98% (HPLC)

Synonym(s):

1-(2,4,6-Trihydroxyphenyl)-1-nonanone, 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, CID 3063200

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About This Item

Empirical Formula (Hill Notation):
C15H22O4
CAS Number:
100079-26-3
Molecular Weight:
266.33
UNSPSC Code:
12352200
PubChem Substance ID:
329825957
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 25 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=C(O)C(O)=CC(C(CCCCCCCC)=O)=C1

InChI

1S/C15H22O4/c1-2-3-4-5-6-7-8-12(16)11-9-13(17)15(19)14(18)10-11/h9-10,17-19H,2-8H2,1H3

InChI key

NVFRHTFJDGAFQS-UHFFFAOYSA-N

General description

THPN or 1-(3,4,5-Trihydroxyphenyl)nonan-1-one, is a derivative of cytosporone B.

Biochem/physiol Actions

THPN is potent nuclear receptor TR3 (Nur77) antagonist that induces autophagic cell death in melanoma. Co-application of THPN with Akt2 inhibitors significantly represses tumor growth in xenograft mouse model.

Other Notes

air sensitive

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Li L et al
Nature Chemical Biology, 11(5), 339-346 (2015)

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