Skip to Content
Merck
CN
All Photos(1)

Key Documents

Safety Information

SML1500

Sigma-Aldrich

Spadin trifluoroacetate salt

≥95% (HPLC)

Synonym(s):

L-Tyrosyl-L-alanyl-L-prolyl-L-leucyl-L-prolyl-L-arginyl-L-tryptophyl-L-serylglycyl-L-prolyl-L-isoleucylglycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-L-arginine, YAPLPRWSGPIGVSWGLR

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C96H142N26O22 · xC2HF3O2
CAS Number:
1270083-24-3
Molecular Weight:
2012.32 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to beige

shipped in

wet ice

storage temp.

−20°C

SMILES string

N3([C@@H](CCC3)C(=O)N[C@@H](CCCN\C(=N\[H])\N)C(=O)N[C@@H](Cc7c8c([nH]c7)cccc8)C(=O)N[C@@H](CO)C(=O)NCC(=O)N4[C@@H](CCC4)C(=O)N[C@@H]([C@H](CC)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc5c6c([nH]c5)cccc6)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@

InChI

1S/C96H142N26O22/c1-10-53(8)79(90(139)107-46-76(127)118-78(52(6)7)91(140)117-71(49-124)86(135)113-67(41-56-43-104-62-22-13-11-20-59(56)62)81(130)106-45-75(126)110-66(38-50(2)3)84(133)112-65(94(143)144)25-16-34-103-96(100)101)119-89(138)72-26-17-35-120(72)77(128)47-108-82(131)70(48-123)116-85(134)68(42-57-44-105-63-23-14-12-21-60(57)63)114-83(132)64(24-15-33-102-95(98)99)111-87(136)74-28-19-37-122(74)93(142)69(39-51(4)5)115-88(137)73-27-18-36-121(73)92(141)54(9)109-80(129)61(97)40-55-29-31-58(125)32-30-55/h11-14,20-23,29-32,43-44,50-54,61,64-74,78-79,104-105,123-125H,10,15-19,24-28,33-42,45-49,97H2,1-9H3,(H,106,130)(H,107,139)(H,108,131)(H,109,129)(H,110,126)(H,111,136)(H,112,133)(H,113,135)(H,114,132)(H,115,137)(H,116,134)(H,117,140)(H,118,127)(H,119,138)(H,143,144)(H4,98,99,102)(H4,100,101,103)/t53-,54-,61-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,78-,79-/m0/s1

InChI key

WMSPWLIEKXALQP-WSSJNERPSA-N

Biochem/physiol Actions

Spadin is a brain penetrant TREK-1 channel inhibitor that has antidepressant effects in mouse models of depression with a rapid onset of action.
Spadin is a peptide derived from a propeptide released in blood upon Sortilin modification.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000129557
0000128025
0000041280
0000040905
016M4707V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jean Mazella et al.
PLoS biology, 8(4), e1000355-e1000355 (2010-04-21)
Current antidepressant treatments are inadequate for many individuals, and when they are effective, they require several weeks of administration before a therapeutic effect can be observed. Improving the treatment of depression is challenging. Recently, the two-pore domain potassium channel TREK-1

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service