SML1473
Chlorcyclizine
≥98% (HPLC)
Synonym(s):
1-[(4-Chlorophenyl)(phenyl)methyl]-4-methylpiperazine, 1-[(4-Chlorophenyl)phenylmethyl]-4-methyl-piperazine
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About This Item
Empirical Formula (Hill Notation):
C18H21ClN2
CAS Number:
Molecular Weight:
300.83
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3
SMILES string
ClC(C=C1)=CC=C1C(N2CCN(C)CC2)C3=CC=CC=C3
InChI key
WFNAKBGANONZEQ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
oil
color
yellow to orange
storage temp.
2-8°C
Biochem/physiol Actions
Chlorcyclizine is a first-generation antihistamine being studied as a potential treatment for hepatitis C.
Chlorcyclizine is a first-generation antihistamine being studied as a potential treatment for hepatitis C. Chlorcyclizine is believed to inhibit an early stage of HCV infection, targeting viral entry into host cells. Chlorcyclizine inihbited the entry of cell culture-produced HCV with an IC50 value 2.3 nM. In human hepatoma cells and primary human hepatocytes, Chlorcyclizine showed a synergistic effect with other hepatitis C drugs such as ribavirin, interferon, telaprevir, boceprevir, sofosbuvir, daclatasvir, and cyclosporin A.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Zongyi Hu et al.
Cell chemical biology, 27(7), 780-792 (2020-05-11)
Chlorcyclizine (CCZ) is a potent hepatitis C virus (HCV) entry inhibitor, but its molecular mechanism is unknown. Here, we show that CCZ directly targets the fusion peptide of HCV E1 and interferes with the fusion process. Generation of CCZ resistance-associated
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