All Photos(1)
1-[(4-Chlorophenyl)(phenyl)methyl]-4-methylpiperazine, 1-[(4-Chlorophenyl)phenylmethyl]-4-methyl-piperazine
C18H21ClN2
Recommended Products
Assay
≥98% (HPLC)
form
oil
color
yellow to orange
storage temp.
2-8°C
SMILES string
ClC(C=C1)=CC=C1C(N2CCN(C)CC2)C3=CC=CC=C3
InChI
1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3
InChI key
WFNAKBGANONZEQ-UHFFFAOYSA-N
Biochem/physiol Actions
Chlorcyclizine is a first-generation antihistamine being studied as a potential treatment for hepatitis C. Chlorcyclizine is believed to inhibit an early stage of HCV infection, targeting viral entry into host cells. Chlorcyclizine inihbited the entry of cell culture-produced HCV with an IC50 value 2.3 nM. In human hepatoma cells and primary human hepatocytes, Chlorcyclizine showed a synergistic effect with other hepatitis C drugs such as ribavirin, interferon, telaprevir, boceprevir, sofosbuvir, daclatasvir, and cyclosporin A.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Cell chemical biology, 27(7), 780-792 (2020-05-11)
Chlorcyclizine (CCZ) is a potent hepatitis C virus (HCV) entry inhibitor, but its molecular mechanism is unknown. Here, we show that CCZ directly targets the fusion peptide of HCV E1 and interferes with the fusion process. Generation of CCZ resistance-associated
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