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SML1461

Sigma-Aldrich

Kyotorphin acetate salt

≥98% (HPLC)

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Synonym(s):
(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid acetate salt, KTP, L-tyrosyl-L-arginine acetate salt, Tyr-Arg acetate salt, Tyrosyl-Arginine acetate salt
Empirical Formula (Hill Notation):
C15H23N5O4 · xC2H4O2
CAS Number:
70904-56-2
Molecular Weight:
337.37 (free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329825895
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 20 mg/mL, clear

storage temp.

−20°C

SMILES string

NC(NCCC[C@@H](C(O)=O)NC([C@@H](N)CC1=CC=C(O)C=C1)=O)=N.C

InChI

1S/C15H23N5O4.CH4/c16-11(8-9-3-5-10(21)6-4-9)13(22)20-12(14(23)24)2-1-7-19-15(17)18;/h3-6,11-12,21H,1-2,7-8,16H2,(H,20,22)(H,23,24)(H4,17,18,19);1H4/t11-,12-;/m0./s1

InChI key

KTMKVRFTDZZFFE-FXMYHANSSA-N

Biochem/physiol Actions

Kyotorphin is a neuroactive dipeptide (Tyr-Arg) shown to have analgesic, neuroprotective, and neuromodulatory properties. It is synthesized in nerve terminals and found in the brain and in cerebro-spinal fluid (CSF). Kyotorphin indirectly stimulates opioid receptors by releasing methionine enkephalin (met-enkephalin). CSF levels are lower in patients with persistent pain and in patients with Alzheimer′s disease.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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