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Safety Information

SML1420

Sigma-Aldrich

FSL-1

≥80% (HPLC)

Synonym(s):

(R,S)-Pam2Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe-OH, Fibroblast-stimulating Lipopeptide, Pam2CGDPKHPKSF, S-[2,3-Bis[(1-Oxohexadecyl)oxy]propyl]-L-cysteinylglycyl-L-a-aspartyl-L-prolyl-L-lysyl-L-histidyl-L-prolyl-L-lysyl-L-seryl-L-phenylalanine

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About This Item

Empirical Formula (Hill Notation):
C84H140N14O18S
CAS Number:
322455-70-9
Molecular Weight:
1666.16
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥80% (HPLC)

form

powder

color

white to off-white

solubility

H2O: soluble

storage temp.

−20°C

Related Categories

Biochem/physiol Actions

FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein that acts as a Toll-like Receptor 2/6 (TLR2/6) agonist and activator of nuclear transcription factor NF-KB. FSL-1 is based on the N-terminal part of the 44-kDa lipoprotein LP44 of Mycoplasma salivarium. FSL-1 showed higher stimulatory activity than MALP-2 in its ability to induce TNF-α production in macrophages and NF-κB in TLR2/TLR6 transfected HEK293 cells.
FSL-1 is a bacterial-derived toll-like receptor 2/6 agonist. It is capable of increasing resistance to herpes simplex virus type 2 (HSV-2) infection.

Reconstitution

Reconstitute in endotoxin-free water.

Other Notes

Air sensitive

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

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FSL-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental HSV-2 infection
Rose WA, et al.
Virology Journal, 6, 195-195 (2009)

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