SML1370
A-779 trifluoroacetate salt
≥98% (HPLC)
Synonym(s):
A779 trifluoroacetate salt, Asp1-Arg2-Val3-Tyr4-Ile5-His6-D-Ala7, D-Ala7-Ang-(1-7), DRVYIHA (Modification: Ala-7 = D-Ala), DRVYIHa trifluoroacetate salt, H-Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH trifluoroacetate salt, [7-D-ALA]-angiotensin-(1-7) trifluoroacetate salt
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About This Item
Empirical Formula (Hill Notation):
C39H60N12O11 · xC2HF3O2
CAS Number:
Molecular Weight:
872.97 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
lyophilized powder
color
white to off-white
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
A-779 (D-Ala7-Ang-(1-7)) is a potent and selective antagonist of angiotensin (1-7), an endogenous peptide that acts through activation of a non-AT1, non-AT2 receptor, Mas, and opposes the activity of angiotensin. A-779 has an IC50 of 0.3 nM for Mas with negligible affinity for either AT1R or AT2R.
A-779 is a potent and selective antagonist of angiotensin (1-7).
This blocking angiotensin action affects cardiovascular function.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Cardiovascular actions of angiotensin-(1-7)
Ferreira AJ and Santos RAS
Brazilian journal of medical and biological research, 38(4), 499-507 (2005)
Gustavo B Lamy et al.
Frontiers in physiology, 12, 682711-682711 (2021-07-30)
Central micturition control and urine storage involve a multisynaptic neuronal circuit for the efferent control of the urinary bladder. Electrical stimulation of the lateral preoptic area (LPA) at the level of the decussation of the anterior commissure in cats evokes
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