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Merck
CN

SML1367

EG00229

≥98% (HPLC)

Synonym(s):

N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine

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About This Item

Empirical Formula (Hill Notation):
C17H19N7O5S3
CAS Number:
1018927-63-3
Molecular Weight:
497.57
NACRES:
NA.77
PubChem Substance ID:
329825821
UNSPSC Code:
51111800
MDL number:
MFCD18251520

Key Documents

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InChI

1S/C17H19N7O5S3/c18-17(19)20-7-2-4-11(16(26)27)21-15(25)14-10(6-8-30-14)24-32(28,29)12-5-1-3-9-13(12)23-31-22-9/h1,3,5-6,8,11,24H,2,4,7H2,(H,21,25)(H,26,27)(H4,18,19,20)/t11-/m0/s1

SMILES string

O=C(N[C@H](C(O)=O)CCCNC(N)=N)C1=C(C=CS1)NS(C2=CC=CC3=NSN=C32)(=O)=O

InChI key

ZWWMEDURALZMEV-NSHDSACASA-N

assay

≥98% (HPLC)

form

powder

color

, pale yellow to yellow-orange

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

EG00229 is an antagonist of the VEGF-A receptor neuropilin 1 (NRP1), which decreases viability of A549 lung carcinoma cells. EG00229 impairs VEGFA induced migration of HUV-EC-C endothelial cells.
EG00229 is an antagonist of the VEGF-A receptor neuropilin 1 (NRP1).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
075M4613V

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