All Photos(1)
Synonym(s):
BRD 32048, N2-(4-Methoxyphenyl)-6-(1-piperidinylmethyl)-1,3,5-triazine-2,4-diamine
Empirical Formula (Hill Notation):
C16H22N6O
CAS Number:
Molecular Weight:
314.39
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
SMILES string
NC1=NC(NC2=CC=C(OC)C=C2)=NC(CN3CCCCC3)=N1
InChI
1S/C16H22N6O/c1-23-13-7-5-12(6-8-13)18-16-20-14(19-15(17)21-16)11-22-9-3-2-4-10-22/h5-8H,2-4,9-11H2,1H3,(H3,17,18,19,20,21)
InChI key
PVHJDJWPRZUURH-UHFFFAOYSA-N
Biochem/physiol Actions
BRD32048 is a derivative of [1,3,5]triazine. It is found in orally active phosphodiesterase inhibitors (PDE) inhibitors, DHFR (dihydrofolate reductase) inhibitors and phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors. BRD32048 binds ETS variant 1 (ETV1) and controls transcriptional activity, facilitated by ETV1 and invasion of ETV1-driven cancer cells.
BRD32048 is a potent inhibitor of ETV1 (ETS variant 1) transcription factor oncoprotein. BRD32048 binds ETV1 directly, modulating both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein
Pop MS, et al.
Molecular Cancer Therapeutics, molcanther-molcan0689 (2014)
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