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Safety Information

SML1337

Sigma-Aldrich

NQ301

≥98% (HPLC)

Synonym(s):

2-Chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone, 2-[(4-Acetylphenyl)amino]-3-chloro-1,4-naphthalenedione, Compound 211, NQ 301

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About This Item

Empirical Formula (Hill Notation):
C23H19N3O · HBr
CAS Number:
130089-98-4
Molecular Weight:
434.33
MDL number:
MFCD00559986
UNSPSC Code:
12352200
PubChem Substance ID:
329825795
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

, faint red to dark red

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O

InChI

1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3

InChI key

LSQZKIQSQHZVQS-UHFFFAOYSA-N

Biochem/physiol Actions

NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H315,H319,H335,H400

Hazard Classifications

Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

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