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SML1326

Sigma-Aldrich

PK-THPP

≥98% (HPLC)

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Synonym(s):
1-[1-[6-([1,1′-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone
Empirical Formula (Hill Notation):
C29H32N4O2
CAS Number:
1332454-07-5
Molecular Weight:
468.59
MDL number:
MFCD28396418
UNSPSC Code:
12352200
PubChem Substance ID:
329825786
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 10 mg/mL, clear
DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C(CCC)C(CC1)CCN1C2=C3C(CCN(C(C4=CC=C(C5=CC=CC=C5)C=C4)=O)C3)=NC=N2

InChI

1S/C29H32N4O2/c1-2-6-27(34)23-13-16-32(17-14-23)28-25-19-33(18-15-26(25)30-20-31-28)29(35)24-11-9-22(10-12-24)21-7-4-3-5-8-21/h3-5,7-12,20,23H,2,6,13-19H2,1H3

InChI key

CJZGRIRZVHNUSM-UHFFFAOYSA-N

Biochem/physiol Actions

PK-THPP is a potent antagonist of tandem pore potassium channel subunit TASK-3 (KCNK9, K2P9.1) with an IC50 value of 35 nM for TASK-3 compared to 303 nM for TASK-1 and with >140 fold selectivity over a wider range of potassium channels. PK-THPP was found to act as a respiratory stimulant, stimulating breathing in isoflurane-anesthetized rats.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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