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SML1266

Sigma-Aldrich

Bryostatin 2

≥95% (HPLC)

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Synonym(s):
(+)-Bryostatin 2, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,21,25-Tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-
Empirical Formula (Hill Notation):
C45H66O16
CAS Number:
87745-28-6
Molecular Weight:
863.00
UNSPSC Code:
12352200
NACRES:
NA.77

biological source

Bugula neritina (sponge)

Quality Level

100

Assay

≥95% (HPLC)

form

film

color

colorless to light yellow

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C45H66O16/c1-9-10-11-12-13-14-37(49)59-41-29(21-39(51)56-8)20-32-24-35(27(2)46)58-40(52)23-30(47)22-33-25-36(48)43(5,6)44(53,60-33)26-34-18-28(19-38(50)55-7)17-31(57-34)15-16-42(3,4)45(41,54)61-32/h11-16,19,21,27,30-36,41,46-48,53-54H,9-10,17-18,20,22-26H2,1-8H3/b12-11+,14-13+,16-15+,28-19-,29-21+/t27-,30-,31?,32?,33-,34+,35-,36+,41+,44+,45-/m1/s1

InChI key

LIPGUSBNMQRYNL-WZYRAJGLSA-N

Biochem/physiol Actions

Bryostatin 2 is potent protein kinase C activator (Ki = 5.9 nM) and an antagonist to phorbol ester tumor promoter 12-0-tetradecanoylphorbol-13-acetate (TPA). Bryostatin 2 exhibits antineoplastic activity against the murine P388 lymphocytic leukemia and human U937 cells.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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