SML1176
Carboxypyridostatin trifluoroacetate salt
≥95% (HPLC)
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Synonym(s):
4-[[[2,6-Bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]-1H-1,2,3-triazole-1-propanoic acid trifluoroacetate salt, carboxyPDS trifluoroacetate salt
Empirical Formula (Hill Notation):
C35H34N10O7 · xC2HF3O2
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Quality Level
Assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to light brown
solubility
H2O: 25 mg/mL, clear
storage temp.
−20°C
Application
Carboxypyridostatin trifluoroacetate salt has been used in the study of translation, stimulated by DHX36 (DEAH-box helicase 36) binding at G-rich sites in mRNA untranslated regions.
Biochem/physiol Actions
Carboxypyridostatin (carboxyPDS) selectively stabilizes RNA-containg G-quadruplex stuctures. Immunofluorescent staining of carboxyPDS treated cells using an anti G-quadruplex antibody reveals staining only in the cytoplasm and not the nucleus, demonstrating selectivity against DNA G-quadruplex structures.
Other Notes
Light sensitive
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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DHX36 binding at G-rich sites in mRNA untranslated regions promotes translation.
Sauer M, et al.
bioRxiv (2017)
Pauline Herviou et al.
Nature communications, 11(1), 2661-2661 (2020-05-29)
RNA G-quadruplexes (RG4s) are four-stranded structures known to control mRNA translation of cancer relevant genes. RG4 formation is pervasive in vitro but not in cellulo, indicating the existence of poorly characterized molecular machinery that remodels RG4s and maintains them unfolded.
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