All Photos(1)
Synonym(s):
N-[5-[(4-Bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide, Pitstop-2
Empirical Formula (Hill Notation):
C20H13BrN2O3S2
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to light brown
solubility
DMSO: 20 mg/mL, clear
storage temp.
−20°C
Application
Pitstop 2 has been used as an inhibitor of clathrin-mediated endocytosis.
Biochem/physiol Actions
Pitstop 2 also has an ability to breakdown the nuclear pore complex (NPC) permeability barrier and decrease importin β binding along with alteration of the NPC ultrastructure. Pitstop 2 is also involved in the inhibition of platelet activation, platelet aggregation and secretion.
Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis that acts via blocking ligand access to the clathrin terminal domain. Pitstop 2 selectively inhibits clathrin-mediated HIV entry and stalls clathrin-coated pit (CCP) dynamics.
Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Clathrin inhibitor Pitstop-2 disrupts the nuclear pore complex permeability barrier
Liashkovich I, et al.
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Tingting Dong et al.
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