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Merck
CN

SML1124

CPCCOEt

≥98% (HPLC)

Synonym(s):

7-Hydroxyiminocyclopropan[b]chromen-1α-carboxylic acid ethyl ester

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About This Item

Empirical Formula (Hill Notation):
C13H13NO4
CAS Number:
179067-99-3
Molecular Weight:
247.25
NACRES:
NA.77
PubChem Substance ID:
329825663
UNSPSC Code:
12352200
MDL number:
MFCD00947859

Key Documents

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InChI

1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-

SMILES string

O=C(OCC)C(C1)(OC2=C/3C=CC=C2)C1C3=N/O

InChI key

FXCTZFMSAHZQTR-KAMYIIQDSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

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Biochem/physiol Actions

CPCCOEt is a selective non-competitive metabotropic glutamate receptor mGluR1 antagonist with no agonist or antagonist activity at mGlu2, 4a, 5a, 7b, 8a or ionotropic receptors at concentrations of up to 100 μM.
CPCCOEt is a selective non-competitive metabotropic glutamate receptor mGluR1 antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000509927
0000509927
0000439831
0000439832
0000439831

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Carrie Bowman Dalley et al.
The Journal of pharmacology and experimental therapeutics, 367(1), 59-70 (2018-07-29)
Glioma refers to malignant central nervous system tumors that have histologic characteristics in common with glial cells. The most prevalent type, glioblastoma multiforme, is associated with a poor prognosis and few treatment options. On the basis of reports of aberrant
Bo Liu et al.
Brain research, 1704, 241-248 (2018-10-23)
Glioma is a primary brain tumor with high frequency and dismal prognosis. As there is no permanent cure available, identifying new therapy or mediator to augment the effectiveness of existing therapy is urgently needed. In the current study we tested
Ivar S Stein et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(19), 3741-3750 (2020-04-24)
Structural plasticity of dendritic spines is a key component of the refinement of synaptic connections during learning. Recent studies highlight a novel role for the NMDA receptor (NMDAR), independent of ion flow, in driving spine shrinkage and LTD. Yet little
Jin Bao et al.
eLife, 9 (2020-05-14)
Type 1 metabotropic glutamate receptors (mGluR1s) are key elements in neuronal signaling. While their function is well documented in slices, requirements for their activation in vivo are poorly understood. We examine this question in adult mice in vivo using 2-photon
Karima Ait Ouares et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(9), 1795-1809 (2020-01-24)
In mouse cerebellar Purkinje neurons (PNs), the climbing fiber (CF) input provides a signal to parallel fiber (PF) synapses, triggering PF synaptic plasticity. This signal is given by supralinear Ca2+ transients, associated with the CF synaptic potential and colocalized with
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