All Photos(1)
Synonym(s):
9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid sodium salt, Nedocromil disodium salt
Empirical Formula (Hill Notation):
C19H15NO7 · 2 Na
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
, white to beige to brown
solubility
H2O: 20 mg/mL, clear
storage temp.
2-8°C
InChI
1S/C19H17NO7.2Na/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11;;/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26);;/q;2*+1/p-2
InChI key
JQEKDNLKIVGXAU-UHFFFAOYSA-L
Biochem/physiol Actions
Nedocromil is a mast cell stabilizer and anti-inflammatory and anti-allergic drug. Nedocromil inhibits the degranulation of mast cells, and prevents the activation of and mediator release from a variety of inflammatory cell types. Nedocromil inhibits release of histamine, leukotriene C4, and prostaglandin D2, but has no antihistamine, bronchodilator, or corticosteroid activity itself.
Nedocromil is considered to be more effective in treating asthma compared to a placebo.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Is nedocromil sodium effective treatment for asthma?
O'Byrne P M and Cook D
The European Respiratory Journal, 6(1), 5-6 (1993)
Ajantha Sinniah et al.
International immunopharmacology, 32, 87-95 (2016-01-25)
1.We investigated the role of Annexin (ANX)-A1 and its receptor, ALX/FPR2, in the regulation of mast cell degranulation produced by compound 48/80. 2.Both human cord-blood derived mast cells (CBDMCs) and murine bone marrow derived mast cells (BMDMCs) release phosphorylated ANX-A1
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