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Safety Information

SML1089

Sigma-Aldrich

AZ191

≥98% (HPLC)

Synonym(s):

[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine

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About This Item

Empirical Formula (Hill Notation):
C24H27N7O
CAS Number:
1594092-37-1
Molecular Weight:
429.52
MDL number:
MFCD28015098
UNSPSC Code:
12352200
PubChem Substance ID:
329825466

Assay

≥98% (HPLC)

form

powder

color

, white to yellow to light brown

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

CN1C2=CN=CC=C2C(C3=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=NC=C3)=C1

InChI

1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)

InChI key

ZYVXTMKTGDARKR-UHFFFAOYSA-N

Biochem/physiol Actions

AZ191 is a cell permeable, potent and selective inhibitor of DYRK1B that promotes a G1 cell cycle arrest.
AZ191 is a cell permeable, potent and selective inhibitor of DYRK1B.

Other Notes

AZ191 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the AZ191 probe summary on the Chemical Probes Portal website.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000062603
074M4726V

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ElShaddai Z White et al.
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Rajeev Singh et al.
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Hedgehog (Hh) signaling plays important roles in embryonic development and in tumor formation. Apart from the well-established stimulation of the GLI family of transcription factors, Hh ligands promote the phosphorylation and activation of mTOR and AKT kinases, yet the molecular
Courtney Ackeifi et al.
JCI insight, 5(1) (2019-12-11)
Small molecule inhibitors of dual specificity, tyrosine phosphorylation-regulated kinase 1A (DYRK1A), including harmine and others, are able to drive human β cell regeneration. While DYRK1A is certainly a target of this class, whether it is the only or the most
Devon R Blake et al.
Science signaling, 12(590) (2019-07-18)
Stabilization of the MYC oncoprotein by KRAS signaling critically promotes the growth of pancreatic ductal adenocarcinoma (PDAC). Thus, understanding how MYC protein stability is regulated may lead to effective therapies. Here, we used a previously developed, flow cytometry-based assay that

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