All Photos(1)
Synonym(s):
N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
Empirical Formula (Hill Notation):
C20H23BrN8O
Quality Level
Assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
BX-912 is a potent inhibitor of PDK1 (3-Phosphoinositide dependent protein kinase-1). The IC50 values for direct inhibition of kinase activity or inhibition in a cell based assay are 26 nM and 12 nM, respectively. BX-912 inhibits the growth of PC-3 tumor cells grown on soft agar more potently than cells grown on plastic (IC50 = 320 nM vs. 5.5 mM, respectively).
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Munir A Al-Zeer et al.
EBioMedicine, 23, 100-110 (2017-08-15)
The intracellular human bacterial pathogen Chlamydia trachomatis pursues effective strategies to protect infected cells against death-inducing stimuli. Here, we show that Chlamydia trachomatis infection evokes 3-phosphoinositide-dependent protein kinase-1 (PDPK1) signaling to ensure the completion of its developmental cycle, further leading
Sameer S Chopra et al.
Cell systems, 10(1), 66-81 (2019-12-10)
Frequent mutation of PI3K/AKT/mTOR signaling pathway genes in human cancers has stimulated large investments in targeted drugs but clinical successes are rare. As a result, many cancers with high PI3K pathway activity, such as triple-negative breast cancer (TNBC), are treated
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