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Merck
CN

SML1042

Eptifibatide acetate

≥98% (HPLC), GPIIb/IIIa antagonist, powder

Synonym(s):

Cyclo(S,S)-Mpr(Har)GDWPC-NH2 acetate, N6-(Aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-α-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide cyclic (16)-disulfide acetate

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About This Item

Empirical Formula (Hill Notation):
C35H49N11O9S2 · xC2H4O2
CAS Number:
881997-86-0
Molecular Weight:
831.96 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

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Product Name

Eptifibatide acetate, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

shipped in

wet ice

storage temp.

−20°C

Related Categories

General description

Eptifibatide acetate is a cyclic heptapeptide. It is the member of the class arginin-glycin-aspartat-mimetics. Eptifibatide has a short half-life. The drug decreases the risk of myocardial infarction (MI). Eptifibatide acetate might be associated with thrombocytopenia.

Biochem/physiol Actions

Eptifibatide is a specific inhibitor of fibrinogen binding to the platelet membrane integrin glycoprotein GPIIb/IIIa receptor, preventing platelet aggregation. Eptifibatide binds reversibly and competitively.
Eptifibatide is a specific inhibitor of fibrinogen binding to the platelet membrane integrin glycoprotein GPIIb/IIIa receptor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000391179
0000391179
0000198218
0000198217
0000180334

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Recurrent acute thrombocytopenia in the hospitalized patient: Sepsis, DIC, HIT, or antibiotic-induced thrombocytopenia
Rousan TA, et al.
American Journal of Hematology, 85(1), 71-74 (2010)
Clinical review: traumatic brain injury in patients receiving antiplatelet medication
Beynon C, et al.
Critical Care, 16(4), 228-228 (2012)
Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes
Bhatt DL and Topol EJ
JAMA : The Journal of the American Medical Association, 284(12), 1549-1558 (2000)
Eptifibatide: A cyclic peptide that selectively inhibits platelet glycoprotein IIb/IIIa
Heras M and Escolar G
Drugs Today (Barc), 36, 295-311 (2000)
Jaqueline Gomes Rosa et al.
Toxicon : official journal of the International Society on Toxinology, 159, 50-60 (2019-01-25)
Victims of Bothrops jararaca snakebites manifest bleedings, blood incoagulability, platelet dysfunction, and thrombocytopenia, and the latter has been directly implicated in the genesis of hemorrhagic diathesis. We addressed herein the direct effects of B. jararaca venom (BjV) on ex vivo

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