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Safety Information

SML1008

Sigma-Aldrich

C527

≥98% (HPLC)

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Synonym(s):
2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione
Empirical Formula (Hill Notation):
C17H8FNO3
CAS Number:
Molecular Weight:
293.25
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

faintly yellow to dark yellow

solubility

DMSO: 0.3 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C17H8FNO3/c18-10-7-5-9(6-8-10)17-19-13-14(20)11-3-1-2-4-12(11)15(21)16(13)22-17/h1-8H

InChI key

ULJDFEYQOPCCPM-UHFFFAOYSA-N

Biochem/physiol Actions

C527 is a potent inhibitor of the deubiquitinating enzyme complex USP1/UAF1 (IC50 = 0.88 μM). C527 dose dependently inhibits USP1 activity and induced proteasomal degradation of the trasnscriptional regulator ID1 in U20S osteosarcoma cells.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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