SML1008
C527
≥98% (HPLC)
Synonym(s):
2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione
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About This Item
Empirical Formula (Hill Notation):
C17H8FNO3
CAS Number:
Molecular Weight:
293.25
UNSPSC Code:
12352200
NACRES:
NA.77
InChI
1S/C17H8FNO3/c18-10-7-5-9(6-8-10)17-19-13-14(20)11-3-1-2-4-12(11)15(21)16(13)22-17/h1-8H
InChI key
ULJDFEYQOPCCPM-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
faintly yellow to dark yellow
solubility
DMSO: 0.3 mg/mL, clear (warmed)
storage temp.
2-8°C
Biochem/physiol Actions
C527 is a potent inhibitor of the deubiquitinating enzyme complex USP1/UAF1 (IC50 = 0.88 μM). C527 dose dependently inhibits USP1 activity and induced proteasomal degradation of the trasnscriptional regulator ID1 in U20S osteosarcoma cells.
C527 is a potent inhibitor of the deubiquitinating enzyme complex USP1/UAF1.
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