All Photos(1)
Synonym(s):
3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione hydrochloride
Empirical Formula (Hill Notation):
C18H24N2O3S · HCl
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 20 mg/mL, clear
storage temp.
2-8°C
InChI
1S/C18H24N2O3S.ClH/c1-2-3-13-23-15-9-7-14(8-10-15)5-4-6-16-17(21)20(12-11-19)18(22)24-16;/h6-10H,2-5,11-13,19H2,1H3;1H/b16-6-;
InChI key
HADFDMGQKBGVAV-NKBLJONXSA-N
General description
K145 hydrochloride (3-(2-Amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is an analog of sphingosine.
Application
K145 hydrochloride has been used in the analysis of apoptosis.
Biochem/physiol Actions
It has the ability to prevent leukemia cell growth in vitro.
K145 (3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione) is a selective inhibitor of sphingosine kinase-2 (SphK2) and an anticancer agent. K145 selectively inhibited SphK2 in a dose-dependent manner with an IC50 of 4.30 +/- 0.06 μM with no inhibition of SphK1 at concentrations up to 10 μM. K145 significantly suppressed the growth of U937 tumors in nude mice and the growth of JC tumor cells in BALB/c mice.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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Structure?activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors
Congdon M D, et al.
Bioorganic & Medicinal Chemistry Letters, 25(21), 4956-4960 (2015)
Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington?s disease
Di Pardo A, et al.
Scientific Reports, 7(1), 5280-5280 (2017)
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