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SML0993

Sigma-Aldrich

MK-677

≥98% (HPLC)

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Synonym(s):
Crescendo, Ibutamoren mesylate, L-163191, MK-0677, MK-667, N-[1(R)-1,2-Dihydro-1-methanesulfonylspiro-3H-indole-3,4′-piperidin)-1′-yl]carbonyl-2-(phenylmethoxy)-ethyl-2-amino-2-methylpropanamide methanesulfonate
Empirical Formula (Hill Notation):
C27H36N4O5S · CH3SO3H
CAS Number:
159752-10-0
Molecular Weight:
624.77
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C27H36N4O5S.CH4O3S/c1-26(2,28)25(33)29-22(18-36-17-20-9-5-4-6-10-20)24(32)30-15-13-27(14-16-30)19-31(37(3,34)35)23-12-8-7-11-21(23)27;1-5(2,3)4/h4-12,22H,13-19,28H2,1-3H3,(H,29,33);1H3,(H,2,3,4)/t22-;/m1./s1

InChI key

DUGMCDWNXXFHDE-VZYDHVRKSA-N

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Biochem/physiol Actions

It is also known as ibutamoren mesylate. MK-677 is a mimic of growth hormone (GH)-releasing peptide and is orally active.
MK-677 is a potent, non-peptide ghrelin receptor agonist.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism.
Murphy MG, et al.
The Journal of Clinical Endocrinology and Metabolism, 83(2), 320-325 (1998)

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