All Photos(1)
Synonym(s):
Boc-Phe-His-4-amino-5-cyclohexyl-2,4,5-trideoxypentonyl-Leu-(3-dimethylamino) benzylamide N-methylammonium trifluoroacetate salt
Empirical Formula (Hill Notation):
C48H73N8O7 · xC2HF3O2
Molecular Weight:
874.14 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
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General description
Bantag-1 is a peptide-antagonist. It is soluble in aqueous solutions.
Biochem/physiol Actions
Bantag-1 is a very specific, high affinity antagonist of the orphan GPCR Bombesin receptor subtype-3 (BRS-3). The binding affinity of Bantag-1 in BRS-3 expressing cells is 1.3 nM.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Molecular basis for high affinity and selectivity of peptide antagonist, Bantag-1, for the orphan BB3 receptor.
Nakamura T, et al.
Biochemical Pharmacology, 115, 64-76 (2016)
Xiao-Ming Guan et al.
Cell metabolism, 11(2), 101-112 (2010-01-26)
Bombesin receptor subtype 3 (BRS-3) is a G protein coupled receptor whose natural ligand is unknown. We developed potent, selective agonist (Bag-1, Bag-2) and antagonist (Bantag-1) ligands to explore BRS-3 function. BRS-3-binding sites were identified in the hypothalamus, caudal brainstem
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