SML0934
Enfuvirtide acetate salt
≥95% (HPLC)
Synonym(s):
T-20 acetate salt
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About This Item
Empirical Formula (Hill Notation):
C204H301N51O64 · xC2H4O2
CAS Number:
Molecular Weight:
4491.88 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.77
Quality Level
Assay
≥95% (HPLC)
form
powder
storage condition
desiccated
protect from light
color
white to off-white
shipped in
wet ice
storage temp.
−20°C
Amino Acid Sequence
Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu- Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu- Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu- Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2 acetate
General description
Enfuvirtide acetate salt is a linear synthetic peptide made of 36 amino acids. It has an acetylated N-terminus and a carboxamide C-terminus. Enfuvirtide is catabolized with the help of proteolytic enzymes.
Biochem/physiol Actions
Enfuvirtide is an HIV fusion inhibitor used to patients with multi-drug resistant HIV. Enfuvirtide binds to gp41 preventing the creation of an entry pore for the HIV-1 virus.
Other Notes
Light sensitive
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Desk Encyclopedia of Microbiology (2010)
Alexander Herrmann et al.
Scientific reports, 10(1), 1326-1326 (2020-01-30)
Overcoming the global health threat of HIV infection requires continuous pipelines of novel drug candidates. We identified the γ-pyrone polyketides Aureothin/Neoaureothin as potent hits by anti-HIV screening of an extensive natural compound collection. Total synthesis of a structurally diverse group
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Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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