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SML0931

Sigma-Aldrich

Carbimazole

≥98% (HPLC)

Synonym(s):

1-Ethoxycarbonyl-3-methyl-2-thio-4-imidazoline, 1-Methyl-3-carbethoxy-2-thioglyoxalone, 2,3-Dihydro-3-methyl-2-thioxo-1H-imidazole-1-carboxylic acid ethyl ester, Athyromazole, Carbethoxymethimazole, Carbimazol, Ethyl 3-methyl-2-thioimidazoline-1-carboxylate

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About This Item

Empirical Formula (Hill Notation):
C7H10N2O2S
CAS Number:
22232-54-8
Molecular Weight:
186.23
EC Number:
244-854-4
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3

InChI key

CFOYWRHIYXMDOT-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Carbimazole is a pro-drug of methimazole that is an inhibitor of thyroid enzyme thyroperoxidase. Carbimazole is used to treat hyperthyroidism. Also, carbimazole induces phosphorylation of eukaryotic elongation factor eEF2.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Dhanya Muralidharan et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 115(5), 617-623 (2013-03-05)
Animal studies have shown thyroid dysfunction affects salivary gland functioning, however conclusive human studies are lacking. We sought to assess the qualitative and quantitative changes in saliva among subjects with thyroid dysfunction prior to and following treatment. A longitudinal observational
Which antithyroid drug regimen in paediatric Graves' disease?
Daniel Schenk et al.
Clinical endocrinology, 77(6), 806-807 (2012-07-24)
Dinesh Kumar Dhanwal et al.
The Journal of the Association of Physicians of India, 59, 561-562 (2012-02-18)
Hyperthyroidism is associated with bone loss, which is reversible after treatment. The extent of reversibility of loss of bone mass density (BMD) in hyperthyroid patients after treatment especially at forearm is not clear. Therefore, the present study was conducted to
Sarah M A Caney
Journal of feline medicine and surgery, 15(6), 494-502 (2013-04-18)
Hyperthyroidism is the most common feline endocrinopathy. Treatment options comprise anti-thyroid medication, iodine-restricted diet, surgical thyroidectomy and radioiodine. One hundred and eleven owners of hyperthyroid cats completed a detailed survey asking about their experiences and views on the management of
Pinaki Dutta et al.
The Indian journal of medical research, 136(2), 242-248 (2012-09-11)
Hyperthyroidism is associated with increased food intake, energy expenditure and altered body composition. This study was aimed to evaluate the role of adipocytokines in weight homeostasis in patients with hyperthyroidism. Patients (n=27, 11men) with hyperthyroidism (20 Graves' disease, 7 toxic
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