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SML0909

Sigma-Aldrich

Nefopam hydrochloride

≥98% (HPLC)

Synonym(s):

3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride, 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H19NO · HCl
CAS Number:
23327-57-3
Molecular Weight:
289.80
EC Number:
245-585-5
MDL number:
MFCD00012750
UNSPSC Code:
12352200
PubChem Substance ID:
329825616
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

mp

260 °C (dec.) (lit.)

solubility

H2O: 5 mg/mL, clear

storage temp.

2-8°C

SMILES string

Cl.CN1CCOC(c2ccccc2)c3ccccc3C1

InChI

1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

InChI key

CNNVSINJDJNHQK-UHFFFAOYSA-N

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Application

Nefopam hydrochloride has been used as a standard for the quantitative determination of tramadol by gas chromatography–mass spectrometry (GC/MS).

Biochem/physiol Actions

Nefopam is a centrally-acting analgesic drug of the benzoxazocine chemical class. Nefopam is a non-opioid, but has a potentiating effect on morphine and other opioids. Its mechanism of action is not certain, but may involve its action as a dopamine/serotonin/norepinephrine reuptake inhibitor.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301 + H311 + H331

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000379729
0000379728
0000378863
0000379729
0000379728

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P Deras et al.
Annales francaises d'anesthesie et de reanimation, 32(6), 402-408 (2013-06-01)
To assess the improvement of practices in postoperative analgesia after a cesarean section post implementation of a corrective program. Prospective impact study. After obtaining ethics approval, we included all patients undergoing a cesarean section at Montpellier University Hospital during February
Bethan L Richards et al.
The Cochrane database of systematic reviews, 1, CD008921-CD008921 (2012-01-20)
Pain management is a high priority for patients with rheumatoid arthritis (RA). Despite deficiencies in research data, neuromodulators have gained widespread clinical acceptance as adjuvants in the management of patients with chronic musculoskeletal pain. The aim of this review was
Farès Moustafa et al.
Emergency medicine journal : EMJ, 30(2), 143-148 (2012-03-20)
Renal colic pain is a frequent cause of emergency department admissions (1-2% of admissions). It is extremely painful, often requiring intravenous morphine titration. The aim of this study was to estimate the effect of adding nefopam to ketoprofen upon subsequent
Mahmood Ahmad et al.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 21(3), 271-276 (2011-11-30)
To study the pharmacokinetics and comparative bioavailability of nefopam tablets (Acupan®). Experimentation of this study was based on a single-dose, two-sequence, cross-over randomized design using 12 fasting healthy Pakistani male young subjects. This validated LC/MS method was applied to a
Bethan L Richards et al.
The Journal of rheumatology. Supplement, 90, 28-33 (2012-09-04)
To determine the efficacy and safety of neuromodulators for pain management in patients with inflammatory arthritis. A Cochrane systematic review was performed as part of the 3e Initiative on pain management in inflammatory arthritis. We searched Medline, Embase, and Cochrane
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