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SML0835

Sigma-Aldrich

PF74

≥98% (HPLC)

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Synonym(s):
2-Methyl-N-[(1S)-2-(methylphenylamino)-2-oxo-1-(phenylmethyl)ethyl]- 1H-indole-3-acetamide, PF 3450074, PF-3450074
Empirical Formula (Hill Notation):
C27H27N3O2
CAS Number:
1352879-65-2
Molecular Weight:
425.52
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

InChI

1S/C27H27N3O2/c1-19-23(22-15-9-10-16-24(22)28-19)18-26(31)29-25(17-20-11-5-3-6-12-20)27(32)30(2)21-13-7-4-8-14-21/h3-16,25,28H,17-18H2,1-2H3,(H,29,31)/t25-/m0/s1

InChI key

ACDFWSNAQWFRRF-VWLOTQADSA-N

Biochem/physiol Actions

PF74 (PF-3450074) is a HIV-1 inhibitor that targets HIV capsid protein. PF74 binds specifically to HIV-1 particles and triggers premature HIV-1 uncoating in target cells.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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D S Heller et al.
International journal of fertility, 37(5), 283-285 (1992-09-01)
Patients with complete androgen insensitivity syndrome rarely have Müllerian remnants. A patient with this syndrome found to have a microscopic fallopian tube at the time of gonadectomy is described and possible etiologies for the finding are discussed.
Doortje Borrenberghs et al.
Scientific reports, 6, 36485-36485 (2016-11-11)
Nuclear entry is a selective, dynamic process granting the HIV-1 pre-integration complex (PIC) access to the chromatin. Classical analysis of nuclear entry of heterogeneous viral particles only yields averaged information. We now have employed single-virus fluorescence methods to follow the
Ashwanth C Francis et al.
Cell host & microbe, 23(4), 536-548 (2018-04-13)
The HIV-1 core consists of capsid proteins (CA) surrounding viral genomic RNA. After virus-cell fusion, the core enters the cytoplasm and the capsid shell is lost through uncoating. CA loss precedes nuclear import and HIV integration into the host genome
Alžběta Dostálková et al.
Molecules (Basel, Switzerland), 25(8) (2020-04-25)
A major structural retroviral protein, capsid protein (CA), is able to oligomerize into two different hexameric lattices, which makes this protein a key component for both the early and late stages of HIV-1 replication. During the late stage, the CA
Doortje Borrenberghs et al.
Scientific reports, 6, 36485-36485 (2016-11-11)
Nuclear entry is a selective, dynamic process granting the HIV-1 pre-integration complex (PIC) access to the chromatin. Classical analysis of nuclear entry of heterogeneous viral particles only yields averaged information. We now have employed single-virus fluorescence methods to follow the
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