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SML0784

BMS-303141

≥98% (HPLC), ATP citrate lyase inhibitor, powder

Synonym(s):

3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1′-biphenyl]-3-yl)-benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C19H15Cl2NO4S
CAS Number:
943962-47-8
Molecular Weight:
424.30
MDL number:
MFCD25976797
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

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Product Name

BMS-303141, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=S(NC1=C(OC)C=CC(C2=CC=CC=C2)=C1)(C3=C(O)C(Cl)=CC(Cl)=C3)=O

InChI

1S/C19H15Cl2NO4S/c1-26-17-8-7-13(12-5-3-2-4-6-12)9-16(17)22-27(24,25)18-11-14(20)10-15(21)19(18)23/h2-11,22-23H,1H3

InChI key

SIIPNDKXZOTLEA-UHFFFAOYSA-N

Related Categories

Application

BMS-303141 has been used for inhibition of ATP citrate lyase in breast cancer cell lines.

Biochem/physiol Actions

BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL).
BMS-303141 is a potent inhibitor of ATP citrate lyase (ACL). BMS-303141 inhibits lipid synthesis in HepG2 cells with an IC50 of 8 μM, and lowers plasma triglycerides in a murine hyperlipdemia model.

Hazard Statements

H413

Precautionary Statements

P273 - P501

Hazard Classifications

Aquatic Chronic 4

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000466958
0000466958
0000189944
0000189945
0000153622

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Acetyl-CoA carboxylase 1-dependent protein acetylation controls breast cancer metastasis and recurrence
Garcia MR, et al.
Cell Metabolism, 26, 842-855 (2017)
Sanjay R Srivatsan et al.
Science (New York, N.Y.), 367(6473), 45-51 (2019-12-07)
High-throughput chemical screens typically use coarse assays such as cell survival, limiting what can be learned about mechanisms of action, off-target effects, and heterogeneous responses. Here, we introduce "sci-Plex," which uses "nuclear hashing" to quantify global transcriptional responses to thousands
Yi-Jia Li et al.
Cell reports, 39(9), 110870-110870 (2022-06-02)
Overcoming resistance to chemotherapies remains a major unmet need for cancers, such as triple-negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty
Gabriella Assante et al.
Genome medicine, 14(1), 67-67 (2022-06-24)
The incidence of non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing worldwide, but the steps in precancerous hepatocytes which lead to HCC driver mutations are not well understood. Here we provide evidence that metabolically driven histone hyperacetylation in
Massimo Bonora et al.
Cell stem cell, 31(3), 359-377 (2024-03-09)
Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools
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