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Safety Information

SML0745

Sigma-Aldrich

NS6180

≥98% (HPLC)

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Synonym(s):
4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one
Empirical Formula (Hill Notation):
C16H12F3NOS
CAS Number:
353262-04-1
Molecular Weight:
323.33
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C16H12F3NOS/c17-16(18,19)12-5-3-4-11(8-12)9-20-13-6-1-2-7-14(13)22-10-15(20)21/h1-8H,9-10H2

InChI key

ZUIJXKLTUFCDGO-UHFFFAOYSA-N

Biochem/physiol Actions

NS6180 is a novel inhibitor of the intermediate-conductance Ca2+-activated K+ channel (KCa3.1) The IC50 of NS6180 against cloned human KCa3.1 is 9 nM. The compound blocks proliferation and production of IL-2 and IFNγ with sub-micromolar potencies in either ConA or PMA/ionomycin challenged rat splenocytes.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H317,H411

Hazard Classifications

Aquatic Chronic 2 - Skin Sens. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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