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Merck
CN

SML0711

RS504393

≥98% (HPLC)

Synonym(s):

6-Methyl-1′-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4′-piperidin]-2(1H)-one, RS-504393

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About This Item

Empirical Formula (Hill Notation):
C25H27N3O3
CAS Number:
300816-15-3
Molecular Weight:
417.50
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

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Product Name

RS504393, ≥98% (HPLC)

SMILES string

N3(CCC4(OC(=O)Nc5c4cc(cc5)C)CC3)CCc1nc([o]c1C)c2ccccc2

InChI

1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)

InChI key

ODNICNWASXKNNQ-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 1 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Related Categories

Application

RS504393 has been used in mass spectrometry.

Biochem/physiol Actions

RS504393 helps to increase the analgesic potency of morphine and buprenorphine in neuropathic rats. RS504393 has the ability to block the upregulation of pronociceptive factors, like IL-1 (interlukin 1) β, IL-18 (interlukin 18), IL-6 (interlukin 6) and inducible nitric oxide synthase (iNOS), that are induced by chronic constriction injury (CCI).
RS504393 is a highly selective CCR2 chemokine receptor antagonist.
RS504393 is a highly selective CCR2 chemokine receptor antagonist. RS504393 inhibits MCP-1 chemotaxis and ischemia-reperfusion injury in kidneys.

Features and Benefits

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000382442
0000382442
0000209115
0000209118
0000209118

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The RS504393 influences the level of nociceptive factors and enhances opioid analgesic potency in neuropathic rats
Kwiatkowski K, et al.
Journal of Neuroimmune Pharmacology, 12(3), 402-419 (2017)
Chrono-pharmacological Targeting of the CCL2-CCR2 Axis Ameliorates Atherosclerosis
Winter C, et al.
Cell Metabolism (2018)
Bradley W Richmond et al.
Mucosal immunology, 14(2), 431-442 (2020-09-25)
Although activation of adaptive immunity is a common pathological feature of chronic obstructive pulmonary disease (COPD), particularly during later stages of the disease, the underlying mechanisms are poorly understood. In small airways of COPD patients, we found that localized disruption
Maira Licia Foresti et al.
Epilepsy & behavior : E&B, 102, 106695-106695 (2019-12-01)
Neuroinflammation role on epileptogenesis has been the subject of increasing interest. Many studies showed elevation in cytokines and chemokines expression following seizures, such as, CCL2 protein (C-C motif ligand 2 chemokine) and its specific receptor, CCR2. In addition, recent studies

Articles

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