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Safety Information

SML0710

Sigma-Aldrich

DDRI-18

≥98% (HPLC)

Synonym(s):

3,3′-[6,6′-bi-1H-Benzimidazole]-2,2′-diylbis-benzenamine

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About This Item

Empirical Formula (Hill Notation):
C26H20N6
CAS Number:
Molecular Weight:
416.48
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL

storage temp.

2-8°C

SMILES string

NC1=CC=CC(C(N2)=NC(C=C3)=C2C=C3C4=CC5=C(C=C4)N=C(N5)C6=CC(N)=CC=C6)=C1

InChI

1S/C26H20N6/c27-19-5-1-3-17(11-19)25-29-21-9-7-15(13-23(21)31-25)16-8-10-22-24(14-16)32-26(30-22)18-4-2-6-20(28)12-18/h1-14H,27-28H2,(H,29,31)(H,30,32)

InChI key

QROWVLFOWUYBIG-UHFFFAOYSA-N

Biochem/physiol Actions

DDRI-18 (DNA Damage Response Inhibitor-18) inhibits nonhomologous end-joining (NHEJ) DNA repair following double strand DNA breaks induced by ionizing radiation, and enhances the effects of DNA-damaging cancer drugs like etoposide, camptothecin and doxorubicin.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品

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